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KMID : 0378019720150100073
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New Medical Journal
1972 Volume.15 No. 10 p.73 ~ p.76
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Autoradiographic Observation of Appendiceal Lymphoid Tissue in the Immune Mice following Subaxillar Transplantation of Ehrlich Carcinoma
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Abstract
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Littman et al. (1968) reported that a high level of immunity of a long duration against Ehrlich carcinoma was produced in CFA white Swiss mice by UV-irradiated homologous Ehrlich carcinoma ascites tumor cell and suggested that the immunity produced by irradiated, killed tumor cell vaccine was primarily cell mediated. Lee and Kim (1972) reported that from the result of an autoradiographic observation the proliferation of small round cells around the tumor mass was distinct. Kang & Kim (1972) and Koh & Kim (1972) also reported that in the immune mice proliferation of large lymphoid cells in the thymus-dependent area of the spleen and the axillar lymph nodes was prominent.
Recently Parey (1968) postulated that stem cells originating in hemopoietic tissue and differentiating into immunoglobulin and antibody-producing cells could develop and function normally without being directly or indirectly influenced by the thymus gland, whereas this differentiation occurred under the influence of lymphoepithelial tissues of the intestine, especially appendix.
We made an attempt to observe autoradiogaphically the response of the appendiceal lymphoid tissue of the immune mice following subaxillar transplantation of Ehrlich carcinoma.
The results were as follows:
In the immune mice proliferation of large lymphoid cells in the appendiceal lymphoid tissue was prominent 5 days after the subaxillar transplantation of Ehrlich carcinoma.
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